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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
47.27
Human Site:
Y429
Identified Species:
86.67
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
Y429
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Chimpanzee
Pan troglodytes
XP_509099
871
93967
Y462
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
Y462
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Dog
Lupus familis
XP_857182
860
93116
Y429
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
Y462
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Rat
Rattus norvegicus
Q63796
888
96289
Y462
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
Y475
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Frog
Xenopus laevis
A7J1T0
961
107551
Y475
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
Y453
A
L
D
I
R
E
H
Y
E
R
K
L
E
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
R464
K
A
N
L
L
K
I
R
E
Q
N
L
R
E
R
Honey Bee
Apis mellifera
XP_397605
895
101116
Y453
A
Q
D
I
R
E
H
Y
E
R
K
L
E
R
T
Nematode Worm
Caenorhab. elegans
O01700
928
103465
Y445
I
K
D
I
R
N
M
Y
E
M
K
L
K
R
T
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
Y450
A
Q
D
I
R
E
H
Y
E
R
K
L
Q
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
13.3
86.6
53.3
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
40
86.6
60
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
85
8
0
0
0
0
0
0
0
0
0
0
0
0
77
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
93
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
85
0
0
100
0
0
0
77
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
85
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
93
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
0
0
8
0
0
0
0
93
0
8
0
0
% K
% Leu:
0
70
0
8
8
0
0
0
0
0
0
100
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
0
0
0
0
0
0
0
8
0
0
8
0
0
% Q
% Arg:
0
0
0
0
93
0
0
8
0
85
0
0
8
93
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _